diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7ee7221de..21e4f7361 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -28,6 +28,8 @@ Docs: https://docs.openclaw.ai
 
 ### Fixes
 
+- OpenRouter/Anthropic: inject `cache_control` on system prompts for OpenRouter Anthropic models to improve prompt-cache reuse. (#17473) Thanks @rrenamed.
+
 - Providers/OpenRouter: allow pass-through OpenRouter and Opencode model IDs in live model filtering so custom routed model IDs are treated as modern refs. (#14312) Thanks @Joly0.
 - Providers/OpenRouter: default reasoning to enabled when the selected model advertises `reasoning: true` and no session/directive override is set. (#22513) Thanks @zwffff.
 - Providers/OpenRouter: map `/think` levels to `reasoning.effort` in embedded runs while preserving explicit `reasoning.max_tokens` payloads. (#17236) Thanks @robbyczgw-cla.
diff --git a/src/agents/pi-embedded-runner/extra-params.openrouter-cache-control.test.ts b/src/agents/pi-embedded-runner/extra-params.openrouter-cache-control.test.ts
new file mode 100644
index 000000000..1468df855
--- /dev/null
+++ b/src/agents/pi-embedded-runner/extra-params.openrouter-cache-control.test.ts
@@ -0,0 +1,99 @@
+import type { StreamFn } from "@mariozechner/pi-agent-core";
+import type { Context, Model } from "@mariozechner/pi-ai";
+import { AssistantMessageEventStream } from "@mariozechner/pi-ai";
+import { describe, expect, it } from "vitest";
+import { applyExtraParamsToAgent } from "./extra-params.js";
+
+describe("extra-params: OpenRouter Anthropic cache_control", () => {
+  it("injects cache_control into system message for OpenRouter Anthropic models", () => {
+    const payload = {
+      messages: [
+        { role: "system", content: "You are a helpful assistant." },
+        { role: "user", content: "Hello" },
+      ],
+    };
+    const baseStreamFn: StreamFn = (_model, _context, options) => {
+      options?.onPayload?.(payload);
+      return new AssistantMessageEventStream();
+    };
+    const agent = { streamFn: baseStreamFn };
+
+    applyExtraParamsToAgent(agent, undefined, "openrouter", "anthropic/claude-opus-4-6");
+
+    const model = {
+      api: "openai-completions",
+      provider: "openrouter",
+      id: "anthropic/claude-opus-4-6",
+    } as Model<"openai-completions">;
+    const context: Context = { messages: [] };
+
+    void agent.streamFn?.(model, context, {});
+
+    expect(payload.messages[0].content).toEqual([
+      { type: "text", text: "You are a helpful assistant.", cache_control: { type: "ephemeral" } },
+    ]);
+    expect(payload.messages[1].content).toBe("Hello");
+  });
+
+  it("adds cache_control to last content block when system message is already array", () => {
+    const payload = {
+      messages: [
+        {
+          role: "system",
+          content: [
+            { type: "text", text: "Part 1" },
+            { type: "text", text: "Part 2" },
+          ],
+        },
+      ],
+    };
+    const baseStreamFn: StreamFn = (_model, _context, options) => {
+      options?.onPayload?.(payload);
+      return new AssistantMessageEventStream();
+    };
+    const agent = { streamFn: baseStreamFn };
+
+    applyExtraParamsToAgent(agent, undefined, "openrouter", "anthropic/claude-opus-4-6");
+
+    const model = {
+      api: "openai-completions",
+      provider: "openrouter",
+      id: "anthropic/claude-opus-4-6",
+    } as Model<"openai-completions">;
+    const context: Context = { messages: [] };
+
+    void agent.streamFn?.(model, context, {});
+
+    const content = payload.messages[0].content as Array<Record<string, unknown>>;
+    expect(content[0]).toEqual({ type: "text", text: "Part 1" });
+    expect(content[1]).toEqual({
+      type: "text",
+      text: "Part 2",
+      cache_control: { type: "ephemeral" },
+    });
+  });
+
+  it("does not inject cache_control for OpenRouter non-Anthropic models", () => {
+    const payload = {
+      messages: [{ role: "system", content: "You are a helpful assistant." }],
+    };
+    const baseStreamFn: StreamFn = (_model, _context, options) => {
+      options?.onPayload?.(payload);
+      return new AssistantMessageEventStream();
+    };
+    const agent = { streamFn: baseStreamFn };
+
+    applyExtraParamsToAgent(agent, undefined, "openrouter", "google/gemini-3-pro");
+
+    const model = {
+      api: "openai-completions",
+      provider: "openrouter",
+      id: "google/gemini-3-pro",
+    } as Model<"openai-completions">;
+    const context: Context = { messages: [] };
+
+    void agent.streamFn?.(model, context, {});
+
+    expect(payload.messages[0].content).toBe("You are a helpful assistant.");
+  });
+});
diff --git a/src/agents/pi-embedded-runner/extra-params.ts b/src/agents/pi-embedded-runner/extra-params.ts
index df0812c67..3ae690c94 100644
--- a/src/agents/pi-embedded-runner/extra-params.ts
+++ b/src/agents/pi-embedded-runner/extra-params.ts
@@ -290,6 +290,59 @@ function createAnthropicBetaHeadersWrapper(
   };
 }
 
+function isOpenRouterAnthropicModel(provider: string, modelId: string): boolean {
+  return provider.toLowerCase() === "openrouter" && modelId.toLowerCase().startsWith("anthropic/");
+}
+
+type PayloadMessage = {
+  role?: string;
+  content?: unknown;
+};
+
+/**
+ * Inject cache_control into the system message for OpenRouter Anthropic models.
+ * OpenRouter passes through Anthropic's cache_control field — caching the system
+ * prompt avoids re-processing it on every request.
+ */
+function createOpenRouterSystemCacheWrapper(baseStreamFn: StreamFn | undefined): StreamFn {
+  const underlying = baseStreamFn ?? streamSimple;
+  return (model, context, options) => {
+    if (
+      typeof model.provider !== "string" ||
+      typeof model.id !== "string" ||
+      !isOpenRouterAnthropicModel(model.provider, model.id)
+    ) {
+      return underlying(model, context, options);
+    }
+
+    const originalOnPayload = options?.onPayload;
+    return underlying(model, context, {
+      ...options,
+      onPayload: (payload) => {
+        const messages = (payload as Record<string, unknown>)?.messages;
+        if (Array.isArray(messages)) {
+          for (const msg of messages as PayloadMessage[]) {
+            if (msg.role !== "system" && msg.role !== "developer") {
+              continue;
+            }
+            if (typeof msg.content === "string") {
+              msg.content = [
+                { type: "text", text: msg.content, cache_control: { type: "ephemeral" } },
+              ];
+            } else if (Array.isArray(msg.content) && msg.content.length > 0) {
+              const last = msg.content[msg.content.length - 1];
+              if (last && typeof last === "object") {
+                (last as Record<string, unknown>).cache_control = { type: "ephemeral" };
+              }
+            }
+          }
+        }
+        originalOnPayload?.(payload);
+      },
+    });
+  };
+}
+
 /**
  * Map OpenClaw's ThinkLevel to OpenRouter's reasoning.effort values.
  * "off" maps to "none"; all other levels pass through as-is.
@@ -426,6 +479,7 @@ export function applyExtraParamsToAgent(
   if (provider === "openrouter") {
     log.debug(`applying OpenRouter app attribution headers for ${provider}/${modelId}`);
     agent.streamFn = createOpenRouterWrapper(agent.streamFn, thinkingLevel);
+    agent.streamFn = createOpenRouterSystemCacheWrapper(agent.streamFn);
   }
 
   // Enable Z.AI tool_stream for real-time tool call streaming.